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Maxeran vs metoclopramide ), for which no differences was found (Supplementary Fig. 2A,B). Table 1 Table 1. Summary scores of the PANAS total and subscale scores. The main results are given along with discussion. Both AOM and MADRS scores were significantly lower for patients with chronic low-dose treatment exposure. In the current sample only, however, metoclopramide treatment resulted in a significantly lower mean score and total PANAS for both AOM and MADRS (both F (1,33) = 9.947, p=0.004 and F (1,13) = 2.637, p=0.062, respectively, for metoclopramide versus placebo). In addition, the effect of drug was significantly greater (P<0.0001) for AOM (mean difference = −0.543 vs −1.846, P=0.001), MADRS (mean difference = −1.863 vs −2.054, P=0.0024), and PANAS total (mean difference = −0.852 vs −1.731, P =0.0005) compared to placebo treatment. To further investigate the overall effects of metoclopramide administration on cognitive function, we analyzed the effect of drug by dose on AOM, MADRS, and PANAS total scores. We found that the higher metoclopramide dose was associated with an increase in MADRS total and a decrease in PANAS total scores ( ). There were no differences between the high- and low-dose groups in the total or subscale scores (see Table 2 ). The effect of drug dose on AOM showed a similar pattern with higher doses associated a decrease in the total PANAS score and a higher decrease in AOM. Table 2 Table 2. Summary scores of the PANAS total, subscale scores, and mean scores. These effects Vardenafil 5mg $114.79 - $1.28 Per pill were more marked compared to the effect of drug on AOM score when was associated with metoclopramide administration, in which treatment resulted a lower total AOM score (, A) and an increase in the PANAS subscale scores (, Cialis without prescription online B). Finally, the data are summarized by subgroup within patients. Patients with comorbid BPD had a significantly higher mean MADRS total score compared to healthy controls (mean difference = −2.983 vs −0.986, P=0.004). In addition, the effects of drug on MADRS total score were similar to the effects of drug on PANAS mean total and subscale scores ( ). There were no differences in comorbid diagnosis between the high- and low-dose groups (data not shown). Patients with mood and anxiety disorders did not differ when it came to the AOM, MADRS, or PANAS subscale scores. The main effects and interactions of drug dose on MADRS and PANAS scores were similar between low- and high dose groups (, A and B in Supplementary Table 2 ). Drug effects on total AOM and subscale scores of were significant in both groups and the results were consistent across all drug doses, regardless of the age groups. No interactions were observed with age, gender, substance use disorders, comorbid mood and anxiety or BPD patients (see Supplementary Table 2 ). There were also no sex related differences between any drug dose groups and the overall results were comparable in the male and female samples (data not shown). As expected, the effect of drug on PANAS score was significantly higher in men than women, but there were no sex-based differences in the total AOM score (p>0.05), PANAS (p<0.05), or t