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3) The number of participants were not well defined (8 cases × 2 controls)
The number of participants who participated according to the study protocol were either
Disulfiram buy online too small or large to permit a proper statistical analysis. These were the two main sources of variability in the sample size and therefore analysis in this meta-analysis is based on the total sample (n = 1787).
4) There are no differences between the main
Inderal 80mg $56.09 - $0.62 Per pill subtypes of SSRI antidepressants
This was the first meta-analysis to show that differences exist between
Buy buspar online cheap the types of antidepressants. For example, SSRIs were associated with significantly better cognitive performance in the ADAS patients with MDD. However, the same was not true for SSRIs in non-MDD patients [2]. Most of the subtypes antidepressants were also found to be equally effective in these subgroups (e.g. SNRIs, SSRIs, PPI, NEIs, MBCT) [29–31].
For more information on the study protocols please see http://journals.lww.com/emdocs/pdf/#search=intro..
References
1. Inderjit P Sood SK et al. Efficacy and safety of antidepressants evaluated in large randomized clinical trials: a systematic review and meta-analysis. Curr Med Res Opin 2011; 26 : 1811 – 16. 2. Elkind RJ Niederle JP et al. Antidepressants for major depressive disorder: a systematic review and meta-analysis. Arch Gen Psychiatry 2011; 69 : 1087 – 99. 3. Kessler RC Steinmetz KJ KS Mechanisms of action antidepressant treatment in major depressive disorder: a systematic review of randomized controlled trials [published correction appeared in Psychiatr Serv 2013; 74(suppl) :S16]. Am J Psychiatry 2005; 162 : 1453 – 63. 4. Antistsychotics as first-line treatment. Int J Neuropsychopharm 2009; 16 : 931 – 46. 5. Antistsychotic agents. Pharmacopsychiatry 2005; 34 : 4 – 29. 6. Fava S Tassi M et al. Effect of treatment with selective and non-selective antipsychotics on depression symptoms in bipolar disorder. J Clin Psychiatry 2013; 77 : 782 – 90. 7. Chiao CM Zhang B et al. Safety and efficacy of olanzapine, risperidone, quetiapine in patients with chronic schizophrenia: the randomized, double-blind, placebo-controlled ALERT-Plus trial. Biol Psychiatry 2012; 73 : 799 – 802. 8. Geddes JE Martin SM et al. Efficacy and tolerability of zileuton in the treatment first-episode depression: a randomized, double-blind, placebo-controlled study. Am J Psychiatry 2013; 170 : 438 – 47. 9. Heber D Tack EB et al. Efficacy and tolerability of levetiracetam in the treatment depression compared with placebo for 2 weeks in older adults: a randomized, double-blind, placebo-controlled study in primary care practice.
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